基本信息

民族：漢族

出生日期：1996年10月

政治面貌：中共黨員

電子郵箱:  wfsong@mail.scuec.edu.cn

教育及工作經歷

?  2024.11 — 至今     中南民族大學藥學院 講師

?  2021.09-2024.06     武漢大學化學與分子科學學院 高分子化學與物理 博士

?  2019.09-2021.06     武漢大學化學與分子科學學院 高分子化學與物理 碩士

?  2015.09-2019.06     武漢大學化學與分子科學學院 應用化學 學士

研究方向

主要從事基于細菌/細胞的生物活性材料用于腫瘤免疫調節和腫瘤精準治療；探索點擊化學在生命系統中分子成像和藥物傳遞的應用新場景；民族藥來源的抗腫瘤藥物的腫瘤靶向遞送。已在ACS Nano，ACS Central Science，Advanced Materials，Nature Biomedical Engineering，Small等核心期刊發表論文11篇。

論文發表

1.     Song Wen-Fang, Zheng Diwei, Zeng Si-Min, Zeng Xuan, Zhang Xian-Zheng*. Targeting to tumor-harbored bacteria for precision tumor therapy. ACS Nano 2022, 16, 17402-17413.

2.     Song Wen-Fang^#, Yao Wei-Qin^#, Chen Qi-Wen, Zheng Diwei, Han Zi-Yi, Zhang Xian-Zheng*. In situ bioorthogonal conjugation of delivered bacteria with gut inhabitants for enhancing probiotics colonization. ACS Central Science 2022, 8, 1306-1317.

3.     Wei-Qin Yao^#, Song Wen-Fang^#, Xin-Chen Deng, Yan-Tong Lin, Ran Meng, Jia-Wei Wang, Wei-Hai Chen*, Xian-Zheng Zhang*. Harnessing the engineered probiotic-nanosystem to remodulate tumor extracellular matrix and regulate tumor-colonizing bacteria for improving pancreatic cancer chemo-immunotherapy. Small, 2025, 21, 2406837.

4.     Song Wen-Fang, Zeng Jinyue, Ji Ping, Han Ziyi, Sun Yunxia, Zhang Xianzheng*. Self-assembled copper-based nanoparticles for glutathione activated and enzymatic cascade-enhanced ferroptosis and immunotherapy in cancer treatment. Small 2023, 8, 2301148.

5.     Zheng Di-Wei^#, Deng Wei-Wei^#, Song Wen-Fang, Wu Cong-Cong, Liu Jie, Hong Sheng, Zhuang Ze-Nan, Cheng Han, Sun Zhi-Jun*, Zhang Xian-Zheng*. Biomaterial-mediated modulation of oral microbiota synergizes with pd-1 blockade in mice with oral squamous cell carcinoma. Nature Biomedical Engineering 2020, 6, 32-43.

6.     Wen-Li, Qi-Wen Chen, Jin-Xuan Fan, Zi-Yi Han, Song Wen-Fang, Xuan Zeng, Zhang Xian-Zheng*. Bacterial biohybrids for invasion of tumor cells promote antigen cross-presentation through gap junction. Advanced Materials 2024, 36, 2402532.

7.     Wang Jia-Wei^#, Chen Qi-Wen^#, Luo Guo-Feng, Ji Ping, Han Zi-Yi, Song Wen-Fang, Chen Wei-Hai*, Zhang Xian-Zheng*. Interference of glucose bioavailability of tumor by engineered biohybrids for potentiating targeting and uptake of antitumor nanodrugs. Nano Letters 2022, 22, 8735-8743.

8.     Wang Jia-Wei^#, Chen Qi-Wen^#, Luo Guo-Feng, Han Zi-Yi, Song Wen-Fang, Yang Juan, Chen Wei-Hai*, Xian-Zheng Zhang*. A self-driven bioreactor based on bacterium-metal-organic framework biohybrids for boosting chemotherapy via cyclic lactate catabolism. ACS Nano 2021, 15, 17870-17884.

9.     Hong Sheng^#, Zheng Di-Wei^#, Zhang Qiu-Ling, Deng Wei-Wei, Song Wen-Fang, Cheng Si-Xue, Sun Zhi-Jun, Xian-Zheng Zhang*. An RGB-emitting molecular cocktail for the detection of bacterial fingerprints. Chemical Science 2020, 11,4403.

10.   Zheng Di-Wei^#, Hong Sheng^#, Zhang Qiu-Ling, Dong Xue, Pan Pei, Song Wen-Fang, Wen Song, Cheng Si-Xue, Zhang Xian-Zheng*. Controllable gelation of artificial extracellular matrix for altering mass transport and improving cancer therapies. Nature Communication 2020, 11:4907.

11.   Zeng Jin-Yue, Wang Xiao-Shuang, Song Wen-Fang, Cheng Han, Xian-Zheng Zhang*. Metal-organic framework mediated multifunctional nanoplatforms for cancer therapy. Advanced Therapeutics 2019, 2, 1800100.

科研項目

國家自然科學基金委員會，面上項目，52073219，基于多肽的腫瘤微環境響應性多功能納米診療系統，2021-01-01至2024-12-31，58萬元，資助期滿，參與。