棋牌游戏平台-棋牌游戏赚钱qq群

sunlittlefly@hotmail.com

博士，教授，碩士生導師。曾在美國西南醫學中心、斯坦福大學諾貝爾獎得主Thomas C. Südhof教授實驗室從事博士后研究，長期從事囊泡轉運與釋放，鈣離子調節神經遞質釋放機制的科學研究工作。在包括Science，Neuron，PNAS，EMBO Rep，J Neurosci等國際著名期刊在內的各類SCI收錄期刊中發表文章20余篇。主持多項國家自然科學基金、湖北省自然科學基金。先后入選國家民委中青年英才計劃及湖北省優秀青年骨干人才計劃。目前主要運用分子/生化，遺傳學，電生理和光學等手段，在生理和病理情況下研究神經系統細胞信號跨膜傳導的時空調節機制，研究重點包括神經遞質釋放分子機制，神經突觸形成與調節機理，神經網絡發育調控，藥物鎮痛機制等。研究成果為診斷、治療重大神經性疾病提供生物學基礎。

近年代表性研究成果（論文、專著、獲獎、專利等）

1.Xiaofei Yang*, Yea Jin Kaeser-Woo*, Zhiping P. Pang, Wei Xu, Thomas C. Südhof. Complexin Clamps Asynchronous Releaseby Blocking a Secondary Ca2+-Sensor via its Accessory a-Helix. Neuron. 2010 Dec 9:68,907-920.

2.Xiaofei Yang, Peng Cao, Thomas C. Südhof. Deconstructing Complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20777-82.

3.Xiaofei Yang#, Dongmei Hou, Wei Jiang, Chen Zhang#. Intercellular protein-protein interactions at synapses. Protein Cell.2014 Jun;5(6):420-44.(#共同通訊作者)

4.Wei Jiang, Rui Hua, Mengping Wei, Chenhong Li, Zilong Qiu, Xiaofei Yang#, Chen Zhang. An optimized method for high-titer lentivirus preparations without ultracentrifugation. Sci Rep. 2015 Sep 8;5:13875. doi: 10.1038/srep13875.(#共同通訊作者)

5.Xiaofei Yang#，Jimin Pei，Yea Jin Kaeser-Woo，Taulant Bacaj，Nick V. Grishin，Thomas C. Südhof#，Evolutionary Conservation of Complexins: From Choanoflagellates to Mice，EMBO Reports，2015，16（10）：1308-1317. (#共同通訊作者)

6.Jihong Gong; Ying Lai; Xiaohong Li; Mengxian Wang; Jeremy Leitz; Yachong Hu; Yunxiang Zhang; Ucheor B. Choi; Daniel Cipriano; Richard A. Pfuetzner; Thomas C. Südhof; XiaofeiYang# ; Axel T. Brunger#; Jiajie Diao#, C-terminal domain of mammalian complexin-1 localizes to highly curved membranes, Proc Natl Acad Sci U S A., 2016.11.22, 113(47): E7590~E7599(#共同通訊作者)

7.Shen Wang ; Ucheor B. Choi ; Jihong Gong ; Xiaoyu Yang; Yun Li; Austin L. Wang; Xiaofei Yang#; Axel T. Brunger#; Cong Ma#, Conformational Changes of Syntaxin Linker Region induced by Munc13s Ignite SNARE-Complex Assembly in Synaptic Exocytosis, The EMBO Journal, 2017.3.15, 36(6): 816~829(#共同通訊作者)

8. Wei Jiang; Mengping Wei; Mengna Liu; Yunlong Pan; Dong Cao; Xiaofei Yang#; Chen Zhang#, Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation, Journal of Neuroscience, 2017.10.11, 37(41): 9828~9843(#共同通訊作者)

9. Yi Yu, Su Chen, Xiaoqiang Mo, Jihong Gong, Chenhong Li, Xiaofei Yang#. Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis. Front Mol Neurosci. 2018 Feb 26;11:61. (#通訊作者)

10.Su Chen, Yi Rong, Mengxue Liu, Song Cheng, Xiangming Liu, Xiaohong Li, Yi Yu, Guangzhong Yang, Xiaofei Yang#. Analgesic Effects of Triterpenoid Saponins From Stauntonia chinensis via Selective Increase in Inhibitory Synaptic Response in Mouse Cortical Neurons. Front Pharmacol. 2018 Nov 12;9:1302.(#共同通訊作者)